BALBI MATILDE

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective therapies, characterized by degeneration of motor neurons and muscle atrophy. Mitochondrial dysfunction, oxidative stress, and inflammatory response are pathognomonic signs of ALS. In this scenario, a crucial role is played by the nuclear erythroid-related...

Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease due to a progressive degeneration of motor neurons (MNs). The aetiology is still largely obscure, and several mechanisms have been proposed, including glutamate (Glu)-mediated excitotoxicity. In this context, group I metabotropic Glu receptors (mGluR1/5) play an active role,...

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INTRODUCTION. Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease characterised by a progressive degeneration of motor neurons (MNs). The aetiology is still largely obscure, and several mechanisms have been proposed, including glutamate (Glu)-mediated excitotoxicity. In this context, group I metabotropic Glu receptors...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by upper and lower motor neurons (MNs) death, with an important contribution of glial cells. We previously demonstrated that the intravenous administration of mesenchymal stem cells (MSCs), prolonged survival probability and ameliorated pathological features...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by upper and lower motor neurons (MNs) death, with an important contribution of glial cells. We previously demonstrated that the intravenous administration of mesenchymal stem cells (MSCs), prolonged survival probability and ameliorated pathological features...