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BALBONI , Beatrice

Last name: BALBONI

First name: Beatrice

2022 (v1)

Publication

Metadata-only

Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives

Barbieri, Federica Bosio, Alessia Graziana Pattarozzi, Alessandra

Background: Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. Methods: We synthesized a small library of novel biguanide-based compounds that were...

Uploaded on: April 14, 2023