BARBARA MARENGO

Drug resistance is a multifactorial phenomenon that limits the action of antibiotics and chemotherapeutics, thus making urgent the development of new therapeutic strategies capable of inducing cytotoxic effects circumventing chemoresistance. Natural and synthetic cationic peptides and polymers has given satisfactory results both in...

New therapeutic agents as antibiotics and chemotherapeutics capable of inducing cytotoxic effects and employed in the treatment of lethal human diseases as cancer and infections need also to circumvent the increasing chemoresistance, which limits their action. Natural and synthetic cationic peptides and polymers have given appealing results...

Human neuroblastoma (NB) is a pediatric tumor, which, after an initial response to therapy, usually develops resistance. Etoposide (ETO) which is a drug commonly used to clinically treat NB, exerts anticancer effects by increasing reactive oxygen species (ROS) generation [1,2]. Similarly, gallic acid (GA), although not specifically in NB...

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In order to identify new agents endowed with antiproliferative activity, our research project aims to design and synthesize new hybrid molecules using the fragment-based strategy. For this purpose, two naturally occurring scaffolds with antiproliferative and antioxidant properties were combined hoping for a synergistic effect. We decided to...