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V

BARON , V

Last name: BARON

First name: V

December 1995 (v1)

Journal article

Metadata-only

A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies.

Gual, Philippe Baron, V Alengrin, F

Insulin-like growth factor I (IGF-I) binding to its receptor results in receptor autophosphorylation and phosphorylation of several cellular substrates. The mechanism by which binding of the ligand to the extracellular receptor domain activates the intracellular kinase remains to be defined. Using polyclonal antibodies against four regions of...

Uploaded on: March 10, 2024
August 1996 (v1)

Journal article

Metadata-only

Insulin receptor-induced phosphorylation of cellular and synthetic substrates is regulated by the receptor beta-subunit C-terminus.

Gual, Philippe Baron, V Alengrin, F

The transmembrane beta-subunits of the insulin receptor possess hormone-sensitive tyrosine kinase activity. To study the role of the C-terminus domain, a rabbit antipeptide antibody directed to the 1294-1317 domain was produced. The antipeptide antibody inhibited the receptor-induced phosphorylation of poly (Glu, Tyr) and synthetic peptides...

Uploaded on: March 10, 2024