BASILICO , N.

The increasing prevalence of drug-resistant Plasmodium falciparum strains led to an urgent priority in the development of new antimalarial drugs. In this scenario, several pyrazole derivatives have been reported as antimalarial agents in the last years. Recently, novel Tri- and Tetrasubstituted pyrazole derivatives showed interesting...

A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes. Most of the new compounds inhibited the growth of Leishmania promastigotes as well...