BAUER , Charlotte

La maladie d'Alzheimer (MA) se caractérise par des pertes de mémoire, des troubles cognitifs et une perte d'autonomie des patients. C'est une maladie rare avant 65 ans. Moins de 2 % des cas de MA surviennent avant cet âge, essentiellement chez des personnes atteintes de formes familiales héréditaires rares. Comme dans toute maladie chronique,...

Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β peptides (Aβ) in the brain. The ectopeptidase, neprilysin (NEP), has been reported as the major Aβ-degrading enzyme in mice and human brains. We have previously shown that NEP expression and activity are...

Keywords: C99 Ab 2ÂTgAD 3ÂTgAD Alzheimer's disease Behavior Actimetry Morris water maze a b s t r a c t The triple transgenic mouse model (3ÂTgAD: APPswe, Tau P301L , PS1 M146V) recapitulates both amyloid b (Ab)-and tau-related lesions as well as synaptic and memory deficits. In these mice, we reported an early apathy-like behavior and...

In physiological conditions, both β-amyloid precursor protein (βAPP) and cellular prion (PrP(c)) undergo similar disintegrin-mediated α-secretase cleavage yielding N-terminal secreted products referred to as soluble amyloid precursor protein-α (sAPPα) and N1, respectively. We recently demonstrated that N1 displays neuroprotective properties by...

Endosomal-autophagic-lysosomal (EAL) dysfunction is an early and prominent neuropathological feature of Alzheimers's disease, yet the exact molecular mechanisms contributing to this pathology remain undefined. By combined biochemical, immunohistochemical and ultrastructural approaches, we demonstrate a link between EAL pathology and the...

Abstract The processing of the amyloid precursor protein (APP) is one of the key events contributing to Alzheimer's disease (AD) etiology. Canonical cleavages by β- and γ-secretases lead to Aβ production which accumulate in amyloid plaques. Recently, the matrix metalloprotease MT5-MMP, referred to as η-secretase, has been identified as a novel...

International audience

The α-secretases A Disintegrin And Metalloprotease 10 (ADAM10) and ADAM17 trigger constitutive and regulated processing of the cellular prion protein (PrPc) yielding N1 fragment. The latter depends on protein kinase C (PKC)-coupled M1/M3 muscarinic receptors activation and subsequent phosphorylation of ADAM17 on its intracytoplasmic threonine...

International audience

International audience