The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is largely responsible for alterations in cell metabolism in hypoxic tumor cells. This transcription factor not only favors cell proliferation through the metabolic shift from oxidative phosphorylation to glycolysis and lactic acid production but also...
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February 28, 2012 (v1)Journal articleUploaded on: December 4, 2022
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March 9, 2009 (v1)Journal article
While HIF is a major actor in the cell survival response to hypoxia, HIF is also associated with cell death. Several studies implicate the HIF-induced putative BH3-only pro-apoptotic genes bnip3 and bnip3L in hypoxia-mediated cell death. We, like others, do not support this assertion. Here we clearly demonstrate that the hypoxic...
Uploaded on: December 3, 2022 -
October 29, 2004 (v1)Journal article
International audience
Uploaded on: December 4, 2022