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BELLUZZI , Elisa

Last name: BELLUZZI

First name: Elisa

2016 (v1)

Publication

Metadata-only

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

Belluzzi, Elisa Gonnelli, Adriano Cirnaru, Maria Daniela

Background Lrrk2, a gene linked to Parkinson's disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the presynaptic site, LRRK2 associates with synaptic vesicles through interaction with a panel of presynaptic proteins. Results Here, we show that LRRK2 kinase...

Uploaded on: April 14, 2023