CONCLUSIONES: 1. Es posible llevar a cabo, mediante reacciones de policondensación en disolución, la preparación de poliamidas arrégicas de tipo AABB a partir de monómeros derivados de una aldopentosa natural y fácilmente asequible como son la L- y la D-arabinosa. 2. Las propiedades y estructura cristalinas de estas poliamidas derivadas de...
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June 13, 2018 (v1)PublicationUploaded on: March 27, 2023
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January 26, 2024 (v1)Publication
A simple redox amphiphilic tri-block copolyurethane capable of assembling in the form of polymersome has been easily synthesized. Thus, the hydrophobic core is constituted by a central block containing multiple disulfide linkages, and the hydrophilic segments are formed by poly(ethylene glycol) methyl ether (mPEG2000). The disulfide-containing...
Uploaded on: January 28, 2024 -
July 6, 2022 (v1)Publication
The capacity of redox D-mannitol-based polyurethanes to modulate the glutathione response under physiological conditions, as well as their effectiveness for sustained and site-specific drug release in the gastrointestinal tract (GIT), have been demonstrated in previous studies. Based on those promising results, our attention has now been drawn...
Uploaded on: March 25, 2023 -
February 25, 2019 (v1)Publication
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis, through the sustained colonic release of RES...
Uploaded on: March 27, 2023 -
June 14, 2021 (v1)Publication
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must...
Uploaded on: March 25, 2023 -
February 20, 2024 (v1)Publication
NMR, ATR-FTIR and Mass Spectra of small molecules and monomers: {1-[3,5-bis(trifluoromethyl)phenyl]-3-cyclohexylthiourea} (TU) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS 3-(Prop-2-yn-1-ylthio)-propane-1,2-diol (1) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS, ESI-HRMS 4-[(Prop-2-yn-1-ylthio)methyl]-1,3-dioxolan-2-one (2) ...
Uploaded on: February 23, 2024 -
February 27, 2023 (v1)Publication
An increase in resistance to key antibiotics has made the need for novel treatments for the gastric colonization of Helicobacter pylori (H. pylori) a matter of the utmost urgency. Recent studies tackling this topic have focused either on the discovery of new compounds to ameliorate therapeutic regimes (such as vonoprazan) or the synthesis of...
Uploaded on: March 1, 2023