BERMUDEZ , Olga

Intracellular signaling by MAP Kinases is involved in many cellular responses and in the regulation of various physiological and pathological conditions. Tight control of the localization and duration of ERK, JNK or p38 MAPK activity is thus a fundamental aspect of cell biology. Several members of the Dual-Specificity Phosphatase (DUSPs) family...

DUSP6/MKP-3 is a cytoplasmic dual-specificity phosphatase specific for the MAP kinases ERK1/2. Previous data have shown that the MEK/ERK axis exerts a retro-control on its own signaling through transcriptional and post-translational regulation of DUSP6. We first confirm the key role of MEK/ERK in maintaining the levels of dusp6 mRNA, while...