BERNHARD WEHRLE-HALLER

5-pyrazolyl urea derivatives represent attractive molecules endowed with interesting pharmaceutical properties. In particular, GeGe-3 showed promising antiangiogenetic activity interfering with MAPK and PI3K signalling pathways and inhibiting proliferation and migration in HUVEC cells. Furthermore, proteomic studies indicated Calreticulin as...

The pyrazolyl urea GeGe-3 was identified as a potential angiogenesis inhibitor, interfering with MAPK and PI3K signaling pathways in HUVEC cells. The compound was able to inhibit cell migration and proliferation and to interfere with the intersegmental tube formation in zebrafish embryos. Furthermore, other investigation led to the...