Novel, densely functionalized 2-methylideneazetidines can be obtained in high yields under mild conditions from the reactions of nitropentadienoates with primary amines, most likely through an aza-Michael addition followed by a 4-exo-trig cyclization. The initial, selective trans arrangement of the C3 and C4 ring hydrogens undergoes...
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2018 (v1)PublicationUploaded on: April 14, 2023
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2019 (v1)Publication
Herein we report a significant, valuable extension of a recently implemented pyrrole benzannulation methodology that, employing versatile nitrodienes from our lab as useful C4 building blocks, led to indole derivatives characterized by unusual patterns of substitution. The 6-nitro-7-arylindoles resulting from suitably derivatized, non-symmetric...
Uploaded on: March 27, 2023