July 4, 2022 (v1)
Patent
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Uploaded on: January 22, 2024
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July 5, 2022 (v1)Patent
No description
Uploaded on: January 22, 2024 -
2021 (v1)Journal article
Membrane contact sites (MCS) are subcellular regions where two organelles appose their membranes to exchange small molecules, including lipids. Structural information on how proteins form MCS is scarce. We designed an in vitro MCS with two membranes and a pair of tethering proteins suitable for cryo-tomography analysis. It includes VAP-A, an ER...
Uploaded on: December 4, 2022 -
2023 (v1)Journal article
Membrane contact sites (MCSs) are heterogeneous in shape, composition, and dynamics. Despite this diversity, VAP proteins act as receptors for multiple FFAT motif-containing proteins and drive the formation of most MCSs that involve the endoplasmic reticulum (ER). Although the VAP-FFAT interaction is well characterized, no model explains how...
Uploaded on: March 25, 2023 -
2023 (v1)Journal article
Schweinfurthins (SWs) are naturally occurring prenylated stilbenes with promising anticancer properties. They act through a novel mechanism of action similar to that of other families of natural compounds. Their known target, oxysterol-binding protein (OSBP), plays a crucial role in controlling the intracellular distribution of cholesterol. We...
Uploaded on: November 25, 2023