BIGNON , Cécile

Chemical warfare agents and pesticides are toxic molecules causing temporary incapacitation or permanent harms leading to the death of people. One of the major routes of contamination is the percutaneous penetration. Skin protection is important to prevent these dangers. The aim of this thesis is to develop new active topical skin protectants...

Due to their small size, nanoparticles possess unique properties such as high absorption or pollutant degradation, making them useful for skin protection against chemicals. By covalently grafting to a hydrophobically modified alkali-soluble emulsion (HASE), a thickening polymer, nanoparticles can be dispersed as gels in water at neutral pH....

Due to their small size, nanoparticles possess unique properties. Cerium oxide nanoparticles have already been studied for their capacity to adsorb and neutralize toxic compounds including organophosphates. By covalently grafting these nanoparticles to a thickening polymer, their potential aggregation resulting in a loss of surface area and...

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To reinforce skin protection against organophosphates (OPs), the development of new topical skin protectants (TSP) has received a great interest. Nanoparticles like cerium dioxide (CeO2) known to adsorb and neutralize OPs are interesting candidates for TSP. However, NPs are difficult to disperse into formulations and they are suspected of...

International audience

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International audience