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BINÉTRUY , B.

Last name: BINÉTRUY

First name: B.

January 2011 (v1)

Journal article

Metadata-only

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.

Jager, J. Corcelle, V. Grémeaux, T.

AIMS/HYPOTHESIS: Extracellular signal-regulated kinase (ERK) activity is increased in adipose tissue in obesity and type 2 diabetes mellitus and strong evidences suggests that it is implicated in the downregulation of insulin signalling and action in the insulin-resistant state. To determine the role of ERK1 in obesity-associated insulin...

Uploaded on: December 3, 2022
February 2005 (v1)

Journal article

Metadata-only

The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis.

Bost, F. Aouadi, M. Caron, L.

Hyperplasia of adipose tissue is critical for the development of obesity, but molecular mechanisms governing normal or pathological recruitment of new adipocytes remain unclear. The extracellular signal-regulated kinase (ERK) pathway plays a pivotal role in many essential cellular functions, such as proliferation and differentiation. Using...

Uploaded on: December 4, 2022