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BINIECKA P.

Last name: BINIECKA P.

2023 (v1)

Publication

Metadata-only

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer

Fratta S. Biniecka P. Moreno-Vargas A. J.

Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for prolifera-tion, therefore NAMPT represents an interesting target for the development of anti-cancer drugs. Several com-pounds, such as FK866 and CHS828, were identified as potent NAMPT inhibitors with strong anti-cancer activity, although none of...

Uploaded on: February 14, 2024
2023 (v1)

Publication

Metadata-only

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Biniecka P. Matsumoto S. Belotti A.

Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production. Despite the high efficacy of several developed NAMPT inhibitors (i.e., FK866 (APO866)) in...

Uploaded on: February 4, 2024