2016 (v1)
Publication
Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells
The receptor tyrosine kinase ERBB2 interacts with HSP90 and is overexpressed in aggressive breast cancers.Therapeutic HSP90 inhibitors, i.e. Geldanamycin (GA), target ERBB2 to degradation. We have previously shown that HSP90 is responsible for the missorting of recycling ERBB2 to degradation compartments. In this study, we used biochemical,...
Uploaded on: April 14, 2023