B

J

BLÁZQUEZ , J.

Last name: BLÁZQUEZ

First name: J.

March 28, 2022 (v1)

Publication

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Effect of RecA inactivation and detoxification systems on the evolution of ciprofloxacin resistance in Escherichia coli

Díaz Díaz, S. Recacha Villamor, Esther García Duque, A.

Background Suppression of SOS response and overproduction of reactive oxygen species (ROS) through detoxification system suppression enhance the activity of fluoroquinolones. Objectives To evaluate the role of both systems in the evolution of resistance to ciprofloxacin in an isogenic model of Escherichia coli. Methods Single-gene deletion...

Uploaded on: March 25, 2023
January 11, 2023 (v1)

Publication

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Synergistic Quinolone Sensitization by Targeting the recA SOS Response Gene and Oxidative Stress

Recacha, E. Machuca, J. García Duque, A.

Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, to enhance fluoroquinolone activity and lethality. Their putative synergistic impact as a strategy to potentiate the efficacy of bactericidal antimicrobial agents such as fluoroquinolones is unknown. We generated Escherichia...

Uploaded on: March 24, 2023