BLIN , Olivier

BACKGROUND: Early Alzheimer's disease (AD) detection using cerebrospinal fluid (CSF) biomarkers has been recommended as enrichment strategy for trials involving mild cognitive impairment (MCI) patients. OBJECTIVE: To model a prodromal AD trial for identifying MRI structural biomarkers to improve subject selection and to be used as surrogate...

Background: Assessment of human brain atrophy in temporal regions using magnetic resonance imaging (MRI), resting state functional MRI connectivity in the left parietal cortex, and limbic electroencephalographic (rsEEG) rhythms as well as plasma amyloid peptide 42 (Aβ42) has shown that each is a promising biomarker of disease progression in...

It is an open issue whether blood biomarkers serve to diagnose Alzheimer's disease (AD) or monitor its progression over time from prodromal stages. Here, we addressed this question starting from data of the European FP7 IMI-PharmaCog/E-ADNI longitudinal study in amnesic mild cognitive impairment (aMCI) patients including biological, clinical,...

Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers of prodromal Alzheimer's disease (AD). Data were collected at baseline and four follow-ups at 6, 12, 18, and 24 months in...

International audience

Background: The amygdala and the hippocampus are two limbic structures that play a critical role in cognition and behavior, however their manual segmentation and that of their smaller nuclei/subfields in multicenter datasets is time consuming and difficult due to the low contrast of standard MRI. Here, we assessed the reliability of the...

Since the publication, in 1961, of P.-M. Duval's Paris Antique, which took stock of what was known at the time on the scale of the Île-de-France region, documentary inflation has been such that it has become almost impossible to control it. The archaeological corpus was in fact considerably enriched, from the 1990s onwards, by preventive...

Des milliers de découvertes surgissent sans cesse sous la truelle des archéologues. Les vestiges d'habitats, de tombes, de sanctuaires ou d'ateliers enrichissent notre patrimoine comme notre compréhension des sociétés passées. Jamais encore ces archives du sol, du Rhin au Finistère, de la baie de Somme à la Corse et dans les terres d'outremer,...