BOI S.

In this work, an innovative approach to covalently anchor cyclodextrins (CDs) on the surface of submicrometric particles, prepared from an equimolar mixture of poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), was developed. The idea of the applied method lays in the potential reactivity of amino CDs towards the polymer functionalities to...

The emergence of fluid instabilities in the relevant limit of vanishing fluid inertia (i.e., arbitrarily close to zero Reynolds number) has been investigated for the well-known Kolmogorov flow. The time-lagged viscosity change from lower to higher values due to shear changes is the crucial ingredient for the instabilities to emerge. This...

Over 85% of human cancers are solid tumors. The effectiveness of anticancer therapy in solid tumors depends on adequate delivery of the therapeutic agent to tumor cells. Inadequate delivery would result in residual tumor cells, which in turn would lead to regrowth of tumors and possibly development of resistant cells. The most prominent option,...

Over 85% of human cancers are solid tumors. The effectiveness of anticancer therapy in solid tumors depends on adequate delivery of the therapeutic agent to tumor cells. Inadequate delivery would result in residual tumor cells, which in turn would lead to regrowth of tumors and possibly development of resistant cells. The most prominent option,...

In this work, the preparation of a novel enzyme carrier based on a polymer multicomponent system was assessed. Indeed, the design of the above system considered several issues that are the need of applying a biodegradable polymer carrier, characterized by a nanometric dimension, thus suitable to diffuse into the dense mucus structure, with...

The process of Ca2+ mediated gelation of alginate and the fabrication of nanoengineered polyelectrolyte capsules were combined for the preparation of alginate microbeads characterized by the presence of well-defined drug loaded microvoids in their volume. The obtained engineered alginate microbeads are described in terms of their morphology,...

Scattering-type scanning near-field optical microscopy (s-SNOM) is currently regarded as a powerful tool for exploring important optical properties at nanoscale resolutions depending only on the size of a sharp tip that is scanned across the sample surface while being excited with a focused laser beam. Recently, it was shown that, among others,...

This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 μm in size. Obtained core-shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and...

Microcapsules of customized shapes offer significant advantages over spherical ones, including enhanced internalization by host cells, improved flow characteristics, and higher packing capacity. In our work, we propose a method for defined-shape polymer capsules fabrication inspired by a traditional "pelmeni" (dumplings) making process. The...