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BOJAROVÁ , Pavla

Last name: BOJAROVÁ

First name: Pavla

March 24, 2022 (v1)

Publication

Metadata-only

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Pingitore, Valeria Martínez Bailén, Macarena Carmona Asenjo, Ana Teresa

Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions from the respective azido/aminohexylpyrrolidine iminosugar precursors. The resulting monomeric and dimeric compounds were screened for inhibition of β-N-acetylglucosaminidase from Jack beans, the plant ortholog of human...

Uploaded on: December 4, 2022