BONFIGLIO S.

Background: Next Generation Sequencing (NGS) has become a valuable tool for molecular landscape characterization of cancer genomes, leading to a better understanding of tumor onset and progression, and opening new avenues in translational oncology. Formalin-fixed paraffin-embedded (FFPE) tissue is the method of choice for storage of clinical...

In order to identify biomarkers able to predict lung cancer risk in women surviving breast cancer, the hormone status and the expression of markers involved in DNA repair, DNA synthesis, and cell division were investigated. Breast cancer patients reporting alteration of DNA-repair machinery (BRCA1/2) and reduction of microtubule dynamicity...

The presence of multiple primary tumors (MPT) in a single patient has been identified with an increasing frequency. A critical issue is to establish if the second tumor represents an independent primary cancer or a metastasis. Therefore, the assessment of MPT clonal origin might help understand the disease behavior and improve the...