International audience
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2005 (v1)Book sectionUploaded on: December 4, 2022
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October 11, 2012 (v1)Journal article
Ethnopharmacological relevance: Uncaria tomentosa (Willd. ex Roem. & Schult.) DC. (Rubiaceae) iswidely used by populations living in South America to treat many ailments associated withinflammatory disorders. Mitraphylline was shown to be the major pentacyclic oxindolic alkaloidpresent in the bark chloroformic extract of this plant. Its...
Uploaded on: December 3, 2022 -
December 30, 2012 (v1)Journal article
Simalikalactone E (SkE) is a quassinoid extracted from a widely used Amazonian antimalarial remedy. Although SkE has previously been shown to have cytostatic and/or cytotoxic activities in some tumor cell lines, its mechanism of action has not yet been characterized. We show here that SkE in the high nanomolar range inhibited the growth of...
Uploaded on: December 3, 2022