International audience
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July 28, 2017 (v1)Journal articleUploaded on: December 4, 2022
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September 15, 2008 (v1)Journal article
Epidermal wound repair is a complex process involving the fine orchestrated regulation of crucial cell functions, such as proliferation, adhesion and migration. Using an in vitro model that recapitulates central aspects of epidermal wound healing, we demonstrate that the transcription factor HIF1 is strongly stimulated in keratinocyte cultures...
Uploaded on: December 4, 2022 -
September 14, 2018 (v1)Journal article
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Uploaded on: December 4, 2022 -
September 21, 2021 (v1)Journal article
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Uploaded on: October 14, 2023 -
December 15, 2015 (v1)Journal article
Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective invasion of cancer cells. Here we unveil that exposure to LIF initiates an epigenetic switch...
Uploaded on: September 5, 2024 -
2019 (v1)Journal article
Dysregulation of extracellular matrix (ECM) deposition and cellular metabolism promotes tumor aggressiveness by sustaining the activity of key growth, invasion, and survival pathways. Yet mechanisms by which biophysical properties of ECM relate to metabolic processes and tumor progression remain undefined. In both cancer cells and...
Uploaded on: December 4, 2022 -
September 20, 2022 (v1)Journal article
Highlights d AXL and c-MET are overexpressed in radiotherapy-and cisplatin-resistant HNSCC d Overexpression of AXL and c-MET contributes to tumor aggressiveness and poor prognosis d Cabozantinib has anti-tumor and anti-metastatic efficacy in mice and zebrafish models d Cabozantinib efficacy is shown on HNSCC biopsies and in one patient after...
Uploaded on: October 14, 2023