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BRACHET , Etienne

Last name: BRACHET

First name: Etienne

2019 (v1)

Journal article

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Synthesis, 3D-structure and stability analyses of NRPa-308, a new promising anti-cancer agent

Brachet, Etienne Dumond, Aurore Liu, Wang-Qing

We report herein the synthesis of a newly described anti-cancer agent, NRPa-308. This compound antagonizes Neuropilin-1, a multi-partners transmembrane receptor overexpressed in numerous tumors, and thereby validated as promising target in oncology. The preparation of NRPa-308 proved challenging because of the ortho-gonality of the amide and...

Uploaded on: December 4, 2022
2021 (v1)

Journal article

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Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma

Dumond, Aurore Brachet, Etienne Durivault, Jérôme

Background: Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable. Hence, new relevant treatments are urgently needed. The VEGFs coreceptors, Neuropilins 1, 2...

Uploaded on: December 4, 2022