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BRAY , Sarah

Last name: BRAY

First name: Sarah

August 26, 2024 (v1)

Publication

Metadata-only

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

De Haro Arbona, F. Javier Roussos, Charalambos Baloul, Sarah

Developmental programming involves the accurate conversion of signalling levels and dynamics to transcriptional outputs. The transcriptional relay in the Notch pathway relies on nuclear complexes containing the co-activator Mastermind (Mam). By tracking these complexes in real time, we reveal that they promote the formation of a dynamic...

Uploaded on: August 27, 2024
April 18, 2023 (v1)

Publication

Metadata-only

Implications of ACC/AHA Versus ESC/EAS LDL‑C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI

Vallejo Vaz, Antonio Javier Bray, Sarah Villa, Guillermo

Purpose Low-density lipoprotein cholesterol (LDL-C) recommendations difer between the 2018 American College of Cardi ology/American Heart Association (ACC/AHA) and 2019 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) (<70 vs.<55 mg/dl,...

Uploaded on: April 19, 2023