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BRICE , Alexis

Last name: BRICE

First name: Alexis

February 5, 2024 (v1)

Publication

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Embracing monogenic Parkinson's disease: the MJFF global genetic PD cohort

Vollstedt, Eva Juliane Schaake, Susen Lohmann, Katja

ABSTRACT: Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and...

Uploaded on: February 7, 2024
November 2009 (v1)

Journal article

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

da Costa, Cristine Alves Sunyach, Claire Giaime, Emilie

Mutations of the ubiquitin ligase parkin account for most autosomal recessive forms of juvenile Parkinson's disease (AR-JP). Several studies have suggested that parkin possesses DNA-binding and transcriptional activity. We report here that parkin is a p53 transcriptional repressor. First, parkin prevented 6-hydroxydopamine-induced caspase-3...

Uploaded on: December 4, 2022