BROUTIN , Isabelle

RND family proteins are transmembrane proteins identified as large spectrum drug transporters. A prototypical case in this superfamily, responsible for antibiotic resistance in selected gram negative bacteria, is AcrB. AcrB forms a trimer, which uses the proton motive force to efflux drugs, implementing a functional rotation mechanism....

RND family proteins are transmembrane proteins identified as large spectrum drug trans-porters involved in multi-drug resistance. A prototypical case in this superfamily, responsiblefor antibiotic resistance in selected gram negative bacteria, is AcrB. AcrB forms a trimer usingthe proton motive force to efflux drugs, implementing a functional...

no abstract

Multidrug resistance has appeared to mitigate the efficiency of anticancer drugs and the possibility of successful cancer chemotherapy. The Hedgehog receptor Patched is a multidrug transporter expressed in several cancers and as such it represents a new target to circumvent chemotherapy resistance. We report herein that paniceins and especially...