BRUDER , Nicolas

Purpose: Surgical indications for pituitary tumors during pregnancy are rare, and are derived from a balance between expected benefits, particularly for maternal benefits, and anesthetic/surgical risks.Methods: A literature review was performed to define the optimal surgical indications for pituitary adenomas (PA) and other pituitary tumors...

IMPORTANCE:Sedative premedication is widely administered before surgery, but little clinical evidence supports its use.OBJECTIVE:To assess the efficacy of sedative premedication on perioperative patient experience.DESIGN, SETTING, AND PARTICIPANTS:A randomized clinical trial, the PremedX study, enrolled 1062 adult patients who were younger than...

The latest French Guidelines for the management in the first 24 hours of patients with severe traumatic brain injury (TBI) were published in 1998. Due to recent changes (intracerebral monitoring, cerebral perfusion pressure management, treatment of raised intracranial pressure), an update was required. Our objective has been to specify the...

To provide clinical practice recommendations and generate a research agenda on mechanical ventilation and respiratory support in patients with acute brain injury (ABI).