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BRUSCHI , Michela

Last name: BRUSCHI

First name: Michela

2023 (v1)

Publication

Metadata-only

Anoxia Rapidly Induces Changes in Expression of a Large and Diverse Set of Genes in Endothelial Cells

Antonelli, Antonella Scarpa, Emanuele Salvatore Bruzzone, Santina

Sinusoidal endothelial cells are the predominant vascular surface of the bone marrow and constitute the functional hematopoietic niche where hematopoietic stem and progenitor cells receive cues for self-renewal, survival, and differentiation. In the bone marrow hematopoietic niche, the oxygen tension is usually very low, and this condition...

Uploaded on: January 31, 2024
2023 (v1)

Publication

Metadata-only

The influence of redox modulation on hypoxic endothelial cell metabolic and proteomic profiles through a small thiol-based compound tuning glutathione and thioredoxin systems

Bruschi, Michela Biancucci, Federica Masini, Sofia

Reduction in oxygen levels is a key feature in the physiology of the bone marrow (BM) niche where hematopoiesis occurs. The BM niche is a highly vascularized tissue and endothelial cells (ECs) support and regulate blood cell formation from hematopoietic stem cells (HSCs). While in vivo studies are limited, ECs when cultured in vitro at low O-2...

Uploaded on: February 4, 2024