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BUCCIARELLI T.

Last name: BUCCIARELLI T.

2010 (v1)

Publication

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Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation

CORSARO, ALESSANDRO THELLUNG DE COURTELARY, STEFANO VILLA, VALENTINA

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Uploaded on: March 31, 2023
2012 (v1)

Publication

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Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure

Sorrentino S. Bucciarelli T. CORSARO, ALESSANDRO

The pathological form of prion protein (PrPSc), as other amyloidogenic proteins, causes a marked increase of membrane permeability. PrPSc extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, although the contribution of this interaction to the molecular mechanism of neurodegeneration process...

Uploaded on: April 14, 2023