The accumulation of senescent cells can drive many age-associated phenotypes and pathologies. Consequently, it has been proposed that removing senescent cells might extend lifespan. Here, we generated two knockin mouse models targeting the best-characterized marker of senescence, p16Ink4a. Using a genetic lineage tracing approach, we found that...
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July 2020 (v1)Journal articleUploaded on: December 3, 2022
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June 1, 2020 (v1)Journal article
The accumulation of senescent cells can drive many age-associated phenotypes and pathologies. Consequently, it has been proposed that removing senescent cells might extend lifespan. Here we generated two knock-in mouse models targeting the bestcharacterized marker of senescence, p16 Ink4a. Using a genetic lineage tracing approach, we found that...
Uploaded on: May 7, 2023 -
December 22, 2016 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
September 14, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022