BURLANDO B.

Rice is used in traditional medicines as a remedy against inflammation, gastrointestinal ailments, hypercholesterolemia, diabetes, and skin diseases. Experimental and clinical evidence indicate that brown rice and bran oil reduce hypercholesterolemia and cardiovascular risk, rice bran is anti-inflammatory and immunostimulatory, the...

Aims: To elucidate the mechanism by which (−)-epigallocatechin-3-gallate (EGCG) mediates intracellular Ca2+ increase in androgen-independent prostate cancer (PCa) cells. Main methods: Following exposure to different doses of EGCG, viability of DU145 and PC3 PCa cells was evaluated by MTT assay and the intracellular Ca2+ dynamics by the...

We performed a mathematical analysis of the dynamic control loops regulating the vasomotor tone of vascular smooth muscle, blood volume, and mean arterial pressure, which involve the arginine vasopressin (AVP) system, the atrial natriuretic peptide system (ANP), and the renin-angiotensin-aldosterone system (RAAS). Our loop analysis of the...

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We propose a model to explain the pathogenesis of Alzheimer's disease (AD) based on the theory that any disease affecting a healthy organism originates from a bistable feedback loop that shifts the system from a physiological to a pathological condition. We focused on the known double inhibitory loop involving the cellular prion protein (PrPC)...