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Last name: CALIENDO
First name: Fabio
Regolazione Mediata da TGF-ß1 del miRNoma di Cellule NK Umane nel Microambiente Tumorale
Activity of human natural killer (NK) cells against cancer cells is deeply suppressed by TGF-beta1, an immunomodulatory cytokine that is released and activated in the tumor microenvironment. Moreover, our previous data showed that TGF-beta1 modifies the chemokine receptor repertoire of NK cells. In particular, it decreases the expression of...
Tyrosine kinase inhibitors (TKIs) are used in the clinical management of hematological neoplasms. Moreover, in solid tumors such as stage 4 neuroblastomas (NB), imatinib showed benefits that might depend on both on-target and immunological off-target effects. We investigated the effects of imatinib and nilotinib on human NK cells, monocytes,...