1984 (v1)
Publication
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1998 (v1)Publication
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1981 (v1)Publication
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2003 (v1)Publication
Neuronal nicotinic acetylcholine receptors (nAChRs) form a family of ACh-gated cation channels made up of different subtypes. They are widely distributed in peripheral and central nervous systems and are involved in complex cerebral processes as learning, memory, nociception, movement, etc. The possibility that subtype-selective ligands be used...
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2015 (v1)Publication
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2008 (v1)Publication
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2011 (v1)Publication
Quinacrine is one of the few molecules tested to treat patients affected by prion diseases, although the clinical outcome is largely unsatisfactory. To identify novel derivatives with higher neuroprotective activity, we evaluated the effects of a small library of acridine derivatives. The 6-chloro-2-methoxyacridine derivatives bearing on...
Uploaded on: April 14, 2023