CANUTO R. A.

We thus applied only one prooxidant stimulus after enriching two hepatoma cell lines (MH1C1 and 7777) with lower concentrations of arachidonic acid (ARA) than those used in previous work, but still able to enhance lipid peroxidation without loss of viability. After pretreatment with ARA and exposure to the prooxidant, the cultured cells were...

Cytotoxic effects related to exposure to benzaldehyde, acetaldehyde, propionaldehyde and valeraldehyde in hepatoma cell lines

Comparative subcellular distribution of benzaldehyde and acetaldehyde dehydrogenase activities in two hepatoma cell lines and in normal hepatocytes.

Hepatoma cells show alterations in the response to oxidative stress (decreased lipid peroxidation) and in xenobiotic metabolism enzymes (decreased P450, increased GST and ALDH3). This study examined the effect of lipid peroxidation on the expression of the above enzymes in two rat hepatoma cell lines (MH1C1 and 7777). To induce oxidative...