1990 (v1)
Publication
No description
Uploaded on: December 5, 2022
C
P
CARLO , Pia
Last name: CARLO
First name: Pia
Institution: UNIGE
Links
-
-
2007 (v1)Publication
To date the most relevant role for the amyloid precursor protein (APP) and for the presenilins (PSs) on Alzheimer's disease (AD) genesis is linked to the amyloid hypothesis, which considers an aberrant formation of amyloid-P pepticles the cause of neurodegeneration. In this view, APP is merely a substrate, cleaved by the -gamma-secretase...
Uploaded on: April 14, 2023 -
1981 (v1)Publication
No description
Uploaded on: April 14, 2023 -
2007 (v1)Publication
The amyloid precursor protein (APP) and the presenilins 1 and 2 are genetically linked to the development of familial Alzheimer disease. APP is a single-pass transmembrane protein and precursor of fibrillar and toxic amyloid- peptides, which are considered responsible for Alzheimer disease neurodegeneration. Presenilins are multipass membrane...
Uploaded on: April 14, 2023 -
1985 (v1)Publication
No description
Uploaded on: December 5, 2022 -
2002 (v1)Publication
No description
Uploaded on: March 31, 2023 -
2006 (v1)Publication
The amyloid precursor protein (APP) is a transmembrane protein with a short cytoplasmic tail whose physiological function is unclear, although it is well documented that the proteolytic processing of APP could influence the development of Alzheimer's disease (AD) through the formation of membrane-bound C-terminal fragments (CTFs) and of...
Uploaded on: April 14, 2023