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Class switching consists in the substitution of the heavy-chain constant region of immunoglobulin M (IgM) with that of IgG, IgA, or IgE. This enables antibodies to acquire new effector functions that are crucial to combat invading pathogens. Class switching usually requires engagement of CD40 on B cells by CD40 ligand (CD40L) on...
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2000 (v1)Publication
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1988 (v1)PublicationSpecific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture.
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1990 (v1)Publication
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