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2013 (v1)PublicationUploaded on: April 14, 2023
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2008 (v1)Publication
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2009 (v1)Publication
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2007 (v1)Publication
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2009 (v1)Publication
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2014 (v1)Publication
Objectives - Reliable assessment of estrogen, progesterone (ER and PR), and HER2 receptor status are essential in breast cancer (BC) treatment. Immunohistochemical methods are limited by intra- and inter-laboratory variability. Furthermore, current methods are not the ideal approach for reproducing the biological continuum of ER, PR, and HER2...
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2008 (v1)Publication
We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between...
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2012 (v1)Publication
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2016 (v1)PublicationSqualene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
SQLE encodes squalene epoxidase, a key enzyme in cholesterol synthesis. SQLE has sporadically been reported among copy-number driven transcripts in multi-omics cancer projects. Yet, its functional relevance has never been subjected to systematic analyses. Here, we assessed the correlation of SQLE copy number (CN) and gene expression (GE) across...
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2005 (v1)Publication
PURPOSE: Bcl-2 overexpression is frequently detected in lymphoid malignancies, being associated with poor prognosis and reduced response to therapy. Here, we evaluated whether Bcl-2 overexpression affects the cytotoxic activity of proteasome inhibitors taken alone or in association with conventional anticancer drugs or tumor necrosis...
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2006 (v1)Publication
Proteasome inhibitors possess potent antitumor activity against a broad spectrum of human malignancies. However, the effects of these compounds on the immune system still have to be clearly determined. In the present study, we have investigated the effects of proteasome inhibitors on dendritic cells (DC), antigen-presenting cells playing a key...
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2010 (v1)Publication
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2013 (v1)Publication
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2015 (v1)Publication
Oral potentially malignant disorders (OPMDs) characterized by the presence of dysplasia and DNA copy number aberrations (CNAs), may reflect chromosomal instability (CIN) and predispose to oral squamous cell carcinoma (OSCC). Early detection of OPMDs with such characteristics may play a crucial role in OSCC prevention. The aim of this study was...
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2010 (v1)Publication
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2010 (v1)Publication
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2014 (v1)Publication
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2010 (v1)Publication
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Uploaded on: March 31, 2023 -
2013 (v1)Publication
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Uploaded on: April 14, 2023 -
2010 (v1)Publication
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Uploaded on: March 31, 2023