Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated cargoes into the internal luminal vesicles (ILVs) of the MVE. Drosophila genes encoding...
-
2014 (v1)PublicationUploaded on: April 14, 2023
-
2010 (v1)Publication
Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that regulate Notch activation in endosomes, we isolated mutants in Drosophila genes that encode subunitsof the vacuolar ATPase (V-ATPase) proton pump. Cells lacking V-ATPase function display...
Uploaded on: May 12, 2023 -
2016 (v1)PublicationIdentification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells
The receptor tyrosine kinase ERBB2 interacts with HSP90 and is overexpressed in aggressive breast cancers.Therapeutic HSP90 inhibitors, i.e. Geldanamycin (GA), target ERBB2 to degradation. We have previously shown that HSP90 is responsible for the missorting of recycling ERBB2 to degradation compartments. In this study, we used biochemical,...
Uploaded on: April 14, 2023 -
2012 (v1)Publication
No description
Uploaded on: April 14, 2023 -
2005 (v1)Publication
No description
Uploaded on: April 14, 2023 -
2012 (v1)Publication
Bisphenol A (BPA) is one of the most abundant endocrine disruptors in the environment, considered as a weak xenoestrogen. BPA has recently become of additional public health concern because of increasing evidence of deleterious effects on metabolism. Dietary intake seems the most important exposure route for BPA, followed by rapid...
Uploaded on: April 14, 2023 -
2013 (v1)Publication
No description
Uploaded on: April 14, 2023 -
2014 (v1)Publication
No description
Uploaded on: April 14, 2023