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J

CAÑAS , Juan Carlos

Last name: CAÑAS

First name: Juan Carlos

September 16, 2022 (v1)

Publication

Metadata-only

A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability

Cañas, Juan Carlos García Rubio, María Luisa García, Alicia

The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be influenced by the chromatin context. This is mainly due to the fact that DNA-RNA hybrids hamper the progression of replication forks, leading to fork stalling and, ultimately, DNA breaks. Through a specific screening of chromatin...

Uploaded on: March 24, 2023