Las mitocondrias son orgánulos que asumen tareas muy diversas y de gran relevancia para la célula eucariota y la homeostasis del organismo (biosíntesis de ATP, apoptosis y señalización celular, entre otros procesos). Esta Tesis Doctoral se centra en el estudio de la participación de la mitocondria en la biología de los progenitores neurales y...
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March 17, 2022 (v1)PublicationUploaded on: December 4, 2022
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December 27, 2023 (v1)Publication
Neurogenesis in developing and adult mammalian brain is a tightly regulated process that relies on neural stem cell (NSC) activity. There is increasing evidence that mitochondrial metabolism affects NSC homeostasis and differentiation but the precise role of mitochondrial function in the neurogenic process requires further investigation. Here,...
Uploaded on: December 29, 2023 -
December 27, 2023 (v1)Publication
Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with restricted exchange of gases in the lung. The main acute O2-sensing organ is the carotid body (CB), which contains neurosecretory chemoreceptor (glomus) cells innervated by sensory fibers whose activation by hypoxia elicits...
Uploaded on: December 29, 2023 -
January 8, 2024 (v1)Publication
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18-hACE2 mouse model of severe coronavirus disease 2019 (COVID-19), we report a spatiotemporal description of SARS-CoV-2 infection and replication through the...
Uploaded on: January 10, 2024