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CAGNOL , Sebastien

Last name: CAGNOL

First name: Sebastien

October 2, 2003 (v1)

Journal article

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

Luciano, Frederic Jacquel, Arnaud Colosetti, Pascal

Bim is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same transcript. We report here that Bim-EL when phosphorylated by Erk1/2 is rapidly degraded via the proteasome pathway. Using different cellular models we evidence that serine...

Uploaded on: December 4, 2022
May 8, 2008 (v1)

Journal article

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Overexpression of cortactin in head and neck squamous cell carcinomas can be uncoupled from augmented EGF receptor expression.

Fantozzi, Ivana Grall, Dominique Cagnol, Sebastien

Background. The gene encoding cortactin, CTTN (locus 11q13), an actin-binding substrate of Src kinases, is frequently amplified in breast and head and neck squamous cell carcinomas (HNSCC) and cortactin overexpression is thought to contribute in a significant way to the invasive phenotype of these tumors. Elevated Epidermal Growth Factor...

Uploaded on: December 4, 2022