CAINERO , I

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Genome structure, expression, and regulation are crucial in maintaining the physiological state of any cell. However, even a single variation in one of these processes can induce genomic instability, leading to different pathologies, including aging and cancer. Our work focuses on a particular model for of laminopathies disease, Hutchinson...

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The genetic condition known as Hutchinson-Gilford Progeria Syndrome (HGPS) causes the early onset of aging symptoms and premature death. HGPS is caused by a single nucleotide mutation in the LMNA gene, resulting in a truncated form of the protein Lamin A known as ΔLA50 or Progerin. This protein modification causes aberrant lamina network...

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Chromatin organization is a well-orchestrated mechanism regulating cellular physiology and its changes are associated with the onset of many diseases, including cancer. Neuroblastoma (NB) is the most common extracranial tumor in childhood, and it shows remarkable heterogeneity in the phenotypes and evolutionary patterns. Although the molecular...

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Optical Nanoscopy deals with designing and developing optical microscopes able to produce images that are rich sources of quantitative information at the nanoscale. This fact offers an unprecedented insight into the molecular mechanisms that govern and determine the fate of living cells, coupled with a large amount of data to be structured. In...

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