CALDERÓN SÁNCHEZ , Eva María

Antecedentes: La cardiopatía isquémica es la principal causa de morbilidad y mortalidad en las sociedades desarrolladas, lo que la hace una patología importante a tener en cuenta. Actualmente, mediante distintos tratamientos clínicos como fibrinolísis, angioplástia o cirugía coronaria se consigue reperfundir la zona infartada, pero las lesiones...

Urocortin-1 (Ucn-1) is an endogenous peptide that protects heart from ischemia and reperfusion (I/R) injuries. Ucn-1 is known to prevent cardiac cell death, but its role in the transcription of specific genes related to survival signaling pathway has not been fully defined. The aim of this study was to investigate the molecular signaling...

Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemiareperfusion (I/R) injuries. However, little is known about their role in posttranscriptional regulation in the process of cardioprotection. Herein, we investigated whether microRNAs play a role in urocortininduced cardioprotection. Administration...

Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality worldwide. Several procedures are used routinely to guarantee the prompt and successful reestablishment of blood flow to preserve the myocardial viability of infarcted...

Voltage-gated Ca2_ channels in arterial myocytes can mediate Ca2_ release from the sarcoplasmic reticulum and, thus, induce contraction without the need of extracellular Ca2_ influx. This metabotropic action of Ca2_ channels (denoted as calcium-channelinduced calcium release or CCICR) involves activation of G proteins and the phospholipase...