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CAMACHO BENÍTEZ , Inés

Last name: CAMACHO BENÍTEZ

First name: Inés

June 13, 2017 (v1)

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Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis

Romero Gómez, Manuel Jover Cobos, María Díaz Gómez, Daniel

AIM: To assess whether portacaval anastomosis (PCA) in rats affects the protein expression and/or activity of glutaminase in kidneys, intestines and in three brain areas of cortex, basal ganglia and cerebellum and to explain the neurological alterations found in hepatic encephalopathy (HE). METHODS: Sixteen male Wistar rats weighing 250-350...

Uploaded on: March 27, 2023
February 2, 2015 (v1)

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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy

Bautista Palomas, Juan Dionisio Campo Castillo, José Antonio del Romero Gómez, Manuel

Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ammonia production in vitro. Methods: Eighty-two cirrhotic patients with type 2 diabetes were included. Forty-one patients...

Uploaded on: March 27, 2023