CAMPARDELLI R.

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Liposomes are spherical vesicles made up of an aqueous core surrounded by phospholipids. These delivery systems (DS) are largely employed as drug carriers in several industrial fields, such as pharmaceutical and nutraceutical fields. The aim of this short review is to provide a fast overview on the main fundamentals of liposomes, thought as a...

Two different strategies for the encapsulation of hydrophobic bioactives within nanoliposomes were attempted. Three model lipophilic antioxidants (farnesol, limonene, linalool) were entrapped in liposomes using emulsions: drug was dissolved in the oil phase of an oil in water emulsion; then, the aqueous emulsion was entrapped in liposomes inner...

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Today, innovation in the food packaging field can be summed up in the concepts of active and intelligent packaging. These two concepts refer to systems capable of interacting and monitoring the storage conditions of packaged food products, allowing them to control their shelf-life and quality at any time to ensure safer products for consumers....

Fluorescein is a synthetic dye used as a marker to monitor the absorption of liposomes into tissues, but its efficient entrapment is still challenging. In this work, we apply a supercritical fluid process that allows the production of liposomes with a high drug encapsulation efficiency. The effects of operating parameters such as the diameter...

In the Supercritical Antisolvent process (SAS), the thermodynamic behavior of complex multicomponent systems can influence the particles' morphology. However, due to the limited thermodynamic data for multicomponent systems, the effect of solutes is often neglected, and the system is considered as pseudo-binary. It has been demonstrated that...

Water jets in systems at low pressure have been frequently stuie an some moels for the preiction of spray cone angle (θ/2), intact-surface break-up length (L1), an intact-core break-up length (L2) have been evelope. Complete stuies of jets in supercritical receiving meium have not been carrie out; for this reason, in this work, an experimental...

In this work, the precipitation of a model compound (cefonicid) from DMSO by Supercritical Antisolvent (SAS) was performed. Various morphologies; i.e., expanded microparticles, microparticles, and nanoparticles were obtained, varying operating conditions. In order to explain these results, high-pressure vapor-liquid phase equilibria (VLEs) of...