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CAMPOCHIARO , Corrado

Last name: CAMPOCHIARO

First name: Corrado

2021 (v1)

Publication

Metadata-only

Failure of first anti-TNF agent in Takayasu's arteritis: to switch or to swap?

Campochiaro, Corrado Tomelleri, Alessandro Galli, Elena

Biologic drugs (bDMARD), especially TNF-α-inhibitors (TNFi), are used in refractory Takayasu's arteritis (TAK) patients. Up to 23% of patients are switched to a different bDMARD because of inefficacy. No data are available on which strategy is more efficient after TNFi failure. The aim of our study is to evaluate whether a switch or swap...

Uploaded on: April 14, 2023
2023 (v1)

Publication

Metadata-only

Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production

Cantoni, Eleonora Merelli, Ivan Stefanoni, Davide

Objective Trained immunity (TI) is a de facto memory program of innate immune cells, characterized by immunometabolic and epigenetic changes sustaining enhanced production of cytokines. TI evolved as a protective mechanism against infections; however, inappropriate activation can cause detrimental inflammation and might be implicated in the...

Uploaded on: February 23, 2024