International audience
The efficacy of anti‐angiogenic treatment by targeting VEGF/VEGF receptors in metastatic clear cell renal cell carcinoma (ccRCC) varies from patient to patient. Discovering the reasons behind this variability could lead to the identification of relevant therapeutic targets. Thus, we investigated the novel splice variants of VEGF that are less...
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Highlights d AXL and c-MET are overexpressed in radiotherapy-and cisplatin-resistant HNSCC d Overexpression of AXL and c-MET contributes to tumor aggressiveness and poor prognosis d Cabozantinib has anti-tumor and anti-metastatic efficacy in mice and zebrafish models d Cabozantinib efficacy is shown on HNSCC biopsies and in one patient after...