2010 (v1)
Publication
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Uploaded on: March 31, 2023
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2012 (v1)Publication
Despite advancements in comprehension of molecular mechanisms governing bone marrow (BM) homing of hematopoietic stem cells, cord blood transplant (CBT) suffers from a slow rate of hematopoietic recovery. Intrabone (IB) injection has been proposed as a method able to improve speed of BM engraftment with respect to conventional IV protocols....
Uploaded on: April 14, 2023 -
2013 (v1)Publication
Purpose: The active form of vitamin D (1,25(OH)2D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascular risk in patients with disorders of mineral...
Uploaded on: March 27, 2023 -
2013 (v1)Publication
The present study was planned to investigate, by means of quantitative FDG-PET, how bariatric surgery (BS) modifies the metabolic pattern of the whole body and different tissues in slightly obese patients with type 2 diabetes mellitus (T2DM). Methods. Before, one and four months after bariatric surgery, twenty-one consecutive slightly obese...
Uploaded on: April 14, 2023 -
2013 (v1)Publication
In the course of metformin treatment, staging abdominal cancer lesions with (18)F-FDG PET images is often hindered by the presence of a high bowel radioactivity. The present study aimed to verify the mechanism underlying this phenomenon. METHODS: Fifty-three mice were submitted to dynamic acquisitions of (18)F-FDG kinetics under fasting...
Uploaded on: April 14, 2023 -
2014 (v1)Publication
PURPOSE: Reversible ischaemia at radionuclide myocardial perfusion imaging (MPI) accurately predicts risk of cardiac death and nonfatal myocardial infarction (major adverse cardiac events, MACE). This prognostic penetrance might be empowered by accounting for exercise tolerance as an indirect index of ischaemia severity. The present study aimed...
Uploaded on: April 14, 2023 -
2013 (v1)Publication
Abstract Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In the present study, we demonstrate that metformin directly inhibits the enzymatic function of hexokinase (HK) I and II in a cell line of triple-negative breast cancer (MDA-MB-231). The...
Uploaded on: April 14, 2023